11C-PIB images of human immunodeficiency virus associated neyrokohnityvnyh disorders.
Authors: resonances BM, Benzinger TL, Thomas J. Christensen J, Venkat R, Teshome M, P Aldea, phage A., D. Holtsman , J. Morris Clifford DB
OBJECTIVE: To evaluate how amyloid-binding agent carbon 11-labeled Pittsburgh Connection B ((11) C-PIB) can differentiate Alzheimer's disease (AD) with the human immunodeficiency virus ( HIV)-related disorders neyrokohnityvnyh (HAND) in middle-aged HIV-infected persons. DESIGN: (11) C-PIB scan, clinical evaluation and cerebrospinal fluid (CSF) analysis was carried out. And (2) and t tests assessed differences in clinical and demographic variables between HIV-infected participants and non-living person observed in Alzheimer's disease research Knight Center (ADRC). Dispersion analysis of the assessment of regional differences in amyloid-b protein 1-42 (Ab42), using (11) C-PIB. SETTING: ADRC and treatment of HIV. PARTICIPANTS: sixteen HIV-infected participants (11 cognitively normal and 5 out of hands) and 19 ADRC participants (8 cognitively normal and 11 with symptoms of AD). MAIN EVENT: average and regional (11) C-PIB binding potential. Results: Participants with symptoms of AD were older (PPP. 001) had lower levels of Ab42 CSF (PPP. 001) and had higher levels of CSF tau (PPP. 001) than in other groups. Regardless of the degree of HIV-infected participants did not increase (11) C-PIB level. Medium and regional binding potentials were increased for the symptomatic lasix drug side effects participants AD (PPP. 001). CONCLUSIONS: The middle-aged HIV-infected participants, even with hands, do not show increased (11) C-PIB levels, while symptomatic individuals AD increased fibrillar Ab42 deposition in cortical and subcortical regions. The observed differences between hand and AD may reflect differences in the metabolism of Ab42. (11) C-PIB can serve as diagnostic biomarkers for selection of symptomatic AD from the hands of middle-aged HIV-infected persons. The future of the transverse and longitudinal studies necessary to evaluate the usefulness of (11) C-PIB in elderly people with arms. .
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